http://bugs.winehq.org/show_bug.cgi?id=29128
--- Comment #8 from Blake Gripling peanuthead_069@yahoo.com 2011-11-20 19:11:38 CST --- (In reply to comment #7)
Do you have HKEY_CLASSES_ROOT\CLSID{5d09b1ca-efde-36c6-a789-0c0b73031865} in your registry? If so, could you attach a .reg file of it?
As a work-around, try native .NET.
The game asks for .NET 3.5 SP1 upon installation, afaik.