https://bugs.winehq.org/show_bug.cgi?id=40942
--- Comment #10 from Bruno Jesus 00cpxxx@gmail.com --- Please also CD to the directory first instead of launching with a full path, in your example using PoL:
$ cd ~/.PlayOnLinux/wineprefix/DAI/drive_c/Games/Dragon\ Age\ Inquisition
$ wine DragonAgeInquisition.exe