https://bugs.winehq.org/show_bug.cgi?id=38436
--- Comment #33 from Kimmo Myllyvirta kimmo.myllyvirta@gmail.com --- (In reply to Zeke Sonxx from comment #32)
I've been testing with CSMT enabled and disabled, -dx10 and -dx11, and the RX480 registry hack enabled and disabled.
Yep, there's not much progress with the nvapi, so the registry hack is needed. I'll continue in bug #42330 with that black screen issue. You could try the alt+enter trick (it may need some retries).