https://bugs.winehq.org/show_bug.cgi?id=44895
--- Comment #10 from jaapbuurman@gmail.com --- We aren't completely sure where the bug is located, but we found a workaround at least. Check this topic for more information: https://forum.lede-project.org/t/solved-strange-wine-league-of-legends-lede-...
I will file a bug report wherever needed as soon as we track down what's causing this issue.