https://bugs.winehq.org/show_bug.cgi?id=48247
--- Comment #2 from Felix Zielcke fzielcke@z-51.de --- As suggested by Zebediah Figura in the other darksiders 2 bug report (https://bugs.winehq.org/show_bug.cgi?id=40591) I used now d3dcompiler_43.dll and d3dcompiler_47.dll as 64bit version from the internet Now it starts and runs without problems.
So the problem seems to be indeed in the d3dcompiler component