https://bugs.winehq.org/show_bug.cgi?id=49752
--- Comment #21 from Roman Pišl rpisl@seznam.cz ---
Does it make sense to try adopt the 'alternative driver' - D2XX for FTDI devices and a shim layer between the FTDI's Linux D2XX driver and application running under Wine? (https://github.com/brentr/wineftd2xx)
If there is a way to use VCP through D2XX driver (emulate a VCP interface through it), then maybe this one and other similar applications could work (probably only for FTDI's chips, quite common anyway).
I don't think this is feasible. COM ports are directly forwarded to serial ports in Wine.
The more realistic is possibly a "proxy application" on the Linux side that talks with the device reliably and emulates what this obscure application running in Wine needs via pseudo terminal to which the COM port is mapped.
But that's all how I can help here as this as I don't have the real device.