https://bugs.winehq.org/show_bug.cgi?id=48726
--- Comment #3 from TL HereInPlainSight+wine@gmail.com --- No problem, thanks for the reply!
I'm using a Redragon M601 mouse, and according to evhz (https://gitlab.com/iankelling/evhz) its polling rate is 500Hz.
ReShade / GShade are post-processing injectors. https://github.com/crosire/reshade is the source for ReShade. I re-tested with the latest ReShade specifically (as it's the open source one), and it still happens. Of note, it only needs to be installed -- it happens even when none of its presets are active.
I spoke with the developer of GShade, and they said that they don't force any sort of framerate syncing, and I have vsync disabled in the game itself. (Frame rate limit is set to unlimited.)