https://bugs.winehq.org/show_bug.cgi?id=45550
--- Comment #28 from gcx61@onet.pl --- (In reply to Andrew Wesie from comment #25)
I believe the freezing issue is a separate bug related to some recent patches to wine-staging unrelated to LoL. I created a new issue for this (#45558).
After removing mentioned patch from Wine staging client works again. After using LoL patches game works too. Thank you for your work.