https://bugs.winehq.org/show_bug.cgi?id=36859
--- Comment #15 from Jeremy White jwhite@codeweavers.com --- Can you pull a +file,+relay trace?
That will be very large, but I won't need most of it. You should find towards the bottom of the log file a sequence that is something like 'OutputDebug...ERROR: Missing Shader 'shaders/font.ksh'". If you can compress and attach the 5,000 lines of the log above that message, including that message, that would be helpful.
You might also try wine 1.8-rc3. And, finally, is this a standalone Don't Starve, or Don't Starve through Steam? (Mine is through Steam).