http://bugs.winehq.org/show_bug.cgi?id=25492
--- Comment #11 from Nikolay Sivov bunglehead@gmail.com 2011-08-01 08:54:19 CDT --- (In reply to comment #10)
Disabling Protected View (File=>Options=>Trust Center=>Trust Center Settings=>uncheck everything) enables Excel, Word, and Powerpoint to open and save xls, doc, and ppt files, without the patch. Disabling has to be done separately for each Office app.
On a clean install you mean? That's good as a workaround, I think I'll try to fix this properly anyway.