http://bugs.winehq.org/show_bug.cgi?id=11890
--- Comment #6 from Austin English austinenglish@gmail.com 2008-03-15 14:25:05 --- (In reply to comment #5)
skynet@debian:~$ wine '/home/skynet/.wine/drive_c/Program Files/eMule0.48a-Mephisto_v1.1-bin/emule.exe'
Don't run apps this way, cd to the directory first, then call it with 'wine emule.exe'.