https://bugs.winehq.org/show_bug.cgi?id=47764
--- Comment #1 from Sveinar Søpler cybermax@dexter.no --- It definitely seems related to mouselook (ie. holding down mousebutton and move/look around) at the same time as using keyboard. Only using keyboard to turn, there is seemingly no problem.
Also i tested the Lutris-4.16 branch (staging-4.16 + TKG proton patches), there is no problem.
Afaik the Lutris branch uses patchsets such as "raw-input.patch" that deals with similar issues as the new winex11.drv patches addresses.