https://bugs.winehq.org/show_bug.cgi?id=55169
--- Comment #11 from kurtosis kurtosis.jones@gmail.com --- Thanks Oliver and Maciej. Quick update, I found D4 actually works on a different workstation, but using almost the exact same NixOS config as the first one. Same NixOS version, 99% same configuration.nix, same GPU, different but same brand mobo (Asus), slightly different CPU (both Xeons).
It's my work workstation that I don't normally install games on, but figured I test D4 on it, and it works there. So this doesn't look like a Wine issue, or even a Lutris one, but a configuration or hardware issue. Thanks and I'll hack at it a bit more and see if I can narrow down the diff.