http://bugs.winehq.org/show_bug.cgi?id=19566
--- Comment #9 from Dan Kegel dank@kegel.com 2010-09-07 08:30:21 CDT --- Created an attachment (id=30615) --> (http://bugs.winehq.org/attachment.cgi?id=30615) +relay,+mmio,+seh log, compressed with rzip
It's DRM of a sort, so it's going to be a pain. Looks like it checks for debuggers. It then does loads and loads of winmm io calls to the encrypted file, and gives up. A trace of the winmm io calls under Windows might be informative.
FWIW, here's a little bit of doc about that format: http://k-du.de/rgss/rgss.html