http://bugs.winehq.org/show_bug.cgi?id=30932
--- Comment #14 from Andrew Aladjev aladjev.andrew@gmail.com 2012-07-01 05:33:21 CDT --- just to summarize my experience after game finished: 1. http://games.1c.ru/mass_effect/?type=file&file_id=696 install official patch for 1c 2. you shouldn't install any native overrides 3. to fix mouse: winecfg -> graphics -> Automatically capture the mouse in full-screen windows
PS on AMD FX processors in 2 missions (1 in the center of the game and 1 close to the end) models of your command and enemies will be shown as black squares. bioware support said that they wont fix this at all http://social.bioware.com/forum/1/topic/131/index/7251342/1