https://bugs.winehq.org/show_bug.cgi?id=39402
--- Comment #41 from Andrew Eikum aeikum@codeweavers.com --- (In reply to Jerry from comment #36)
Created attachment 61771 [details] fallout 4 music skips
There's a lot going on here. I recommend using the pulseaudio driver if you are using pulseaudio. Also I think it is no longer helpful to set PULSE_LATENCY_MSEC, so I suggest removing that if it isn't actually helping you. Finally, there is a known issue with USB devices with certain games. There is a patch attached to bug 28282 that will hopefully help with this. This patch is working its way into wine-staging, but you can try it now.