http://bugs.winehq.org/show_bug.cgi?id=20165
--- Comment #2 from Dmitry Timoshkov dmitry@codeweavers.com 2009-09-27 05:57:10 --- (In reply to comment #0)
If run from the programs menu, X locks up and needs to be restarted.
That's clearly a sign of a bug in your video drivers.