https://bugs.winehq.org/show_bug.cgi?id=33211
--- Comment #6 from Alon Amir aaBlueDragon@gmail.com --- (In reply to Alon Amir from comment #5)
(In reply to hanska2 from comment #4)
Could you try more up to date wine 1.7 series?
Confirmed existence of this bug on wine-1.7.26 using OS X, played around with the registry settings and backbuffer, all that.
Just to emphasise, the mouse movement makes the game slow as hell, try holding still and see the game running smooth, then move the mouse and see the lag.