https://bugs.winehq.org/show_bug.cgi?id=46221
--- Comment #6 from Olivier F. R. Dierick o.dierick@piezo-forte.be --- With pure wine-staging 4.0-rc4 (without patches from bug 45666 and 45667) the game runs fine for me. With wine-staging 4.0-rc4 + patches from bug 45666 and 45667, I get the error message after champion selection.
@Loris: There is a Debian bug report about the primus/nvidia issue: https://bugs.debian.org/cgi-bin/bugreport.cgi?bug=903770 Try to disable stretch-backports before installing libgl1-nvidia-glx:i386. If you still can't get libgl1-nvidia-glx:i386 to install, you should go to the Debian forums for help. You can test 32 bit primus with the debian steam package for instance by running 'primusrun steam'. Steam is a 32 bit app so primus will run in 32 bit mode and fail if it can't find the nvidia driver. When you get primus to work with 32 bit Linux apps, you may retest LoL in Wine, and come back here to give feedback.