http://bugs.winehq.org/show_bug.cgi?id=27129
--- Comment #16 from evanh evanh@clear.net.nz 2011-09-19 11:04:25 CDT --- Cool. You might want to check in on bug 27291 as it appears similar.
Actually, I wouldn't be too surprised if all these bugs are just variations and the virtual desktop workaround is just masking the problem under certain circumstances.