http://bugs.winehq.org/show_bug.cgi?id=27392
--- Comment #6 from David turbolad995@hotmail.co.uk 2011-07-23 11:47:23 CDT --- ANOTHER WAY TO REPRODUCE THIS:
The left and right mouse buttons can stop working - after a level - if you do this: During gameplay, pressing spacebar on the keyboard a few times will effectively "fast forward" a level to complete it much quicker - but then the mouse buttons can stop working...
If you successfully finish a level, the bottom of the screen says to use the left and right mouse buttons; pressing the left mouse button proceeds to the next level, the right mouse button quits to the main menu. It is here that the mouse buttons can stop working, unless you hold <CTRL> and press <Tab> key to come out of Lemmix and then switch back to Lemmix.