https://bugs.winehq.org/show_bug.cgi?id=46107
--- Comment #20 from Louis Lenders xerox.xerox2000x@gmail.com --- Hi, i applied patches from https://bugs.winehq.org/show_bug.cgi?id=46568
Then after winetricks msxml3 msxml6 it got a tiny bit further to crash into IntegratedLibrary.dll (which resides in System folder of Altium)
I was able to get to the Welcome-screen by disabling the IntegratedLibrary.dll (WINEDLLOVERRIDES="integratedlibrary=d" wine X2.EXE; did not test any further
For now this bug looks really like a msxml6 issu