https://bugs.winehq.org/show_bug.cgi?id=50804
--- Comment #5 from Chris Caudle winehq@chriscaudle.org --- (In reply to Chris Caudle from comment #4)
I noticed the same problem, Fedora 33 has wine 6.3 available as an update, the same installation of LTspice runs with the previous version 5.18, fails to start after updating to 6.3 (along with mingw32-wine-gecko and mingw64-wine-gecko 2.47.2).
I forgot to include in my previous comment that I included the console output from successfully running under 5.18 and failing to start under 6.3 for comparison.