https://bugs.winehq.org/show_bug.cgi?id=40898
mirh mirh@protonmail.ch changed:
What |Removed |Added ---------------------------------------------------------------------------- CC| |mirh@protonmail.ch, | |tckocr@gmail.com
--- Comment #5 from mirh mirh@protonmail.ch --- https://pcgamingwiki.com/wiki/Mass_Effect#No_surround_sound IIRC the game is very picky about audio device. And no sound should just happen when there are no suitable outputs. In Windows indeed, worst case scenario is fallback to Generic Software.. In your case I wouldn't know what's the specific matter - maybe "output device name" doesn't match OAL's native implementation one?
CCing a person very knowledgeable of this kind of problems.