https://bugs.winehq.org/show_bug.cgi?id=56470
--- Comment #2 from mirh mirh@protonmail.ch --- Actually, I just tested hl2, mirror's edge and mass effect 2 and they all seem unaffected (well, perhaps there's a 144fps cap now with wined3d, but that's really likely something specific to the nvidia driver, g-sync, and whatnot).
It's only with mass effect 1 that apparently I have this problem.