https://bugs.winehq.org/show_bug.cgi?id=49025
--- Comment #7 from Andrew Wesie awesie@gmail.com --- (In reply to Andrew Wesie from comment #6)
The patch in bug 49007 to revert the offending commit fixes loading the League of Legends client for me. I'm guessing this bug should be marked as either confirmed or dupe.
After further testing, the behavior I'm observing is closer to bug 49013 so my observation is likely to be unproductive. Apologies.