http://bugs.winehq.org/show_bug.cgi?id=26269
--- Comment #12 from blaise mgavl69@juno.com 2011-09-25 17:08:30 CDT --- Got past the -space bar- problem finally after fiddling about a bit. Not sure which step actually takes care of the problem.
renamed to .old everything except under /SharedBinks except Credits and Waterfall renamed to .old 2KG_logo_720P.bik and Logo.bik in BioShock 2/SP/Content/BinkMovies Adjusted Space= in Application Data/Bioshock2/User.ini to read Space=AcceptOrSelect for every instance. Using the -nointro command line switches. No need for the env XMODIFIERS="" switch.
When you load a new game or level it goes straight into the opening movie and level without any -spacebar to continue- input.:) No problems with loading or saving. Happy gaming!