http://bugs.winehq.org/show_bug.cgi?id=28446
--- Comment #2 from A Wine user RandomAccountName@mail.com 2011-09-20 08:46:21 CDT --- Yes, I've been able to run a DirectDraw game (Bloxx It) with Wine on this system using the OpenGL renderer without any major issues (just lower performance than GDI in windowed mode).
Forgot to mention: I tested with a Radeon HD 4250 and fglrx 8.84.60.