http://bugs.winehq.org/show_bug.cgi?id=13725
--- Comment #3 from Austin English austinenglish@gmail.com 2008-06-06 14:02:31 --- (In reply to comment #2)
is just on the desktop - in wine section there is a shortcut to drive_c but it wont come up instead this error is reported.
~/.wine isn't created until you run a wine application. Try running: $ wineboot
And see if it works then.