http://bugs.winehq.org/show_bug.cgi?id=31153
--- Comment #1 from Vincent Povirk madewokherd@gmail.com 2012-07-11 11:21:33 CDT --- 0041:trace:mscoree:corruntimehost_GetDefaultDomain (0x16a980)
[00000042: 0.04410 0] ENTER: System.AppDomain:InitializeLifetimeService ()(this:00FE9FA0[System.AppDomain mscorlib.dll], ) [00000042: 0.04510 0] LEAVE: System.AppDomain:InitializeLifetimeService ()[OBJECT:00000000] wine: Unhandled page fault on read access to 0x00000000 at address 0x500bbd87 (thread 0042), starting debugger...
This is probably another problem with Mono's _AppDomain interface not matching native.