https://bugs.winehq.org/show_bug.cgi?id=45934
--- Comment #3 from Someone scrimekiler@yahoo.fr --- I added a dmixer in the .asoundrc file which turned the ALSA underrun errors into a warning about playback device. It seems the problem comes from the fact LoL is trying to use the capture device + several sound channels I didn't try to use an asym yet
I installed pulseaudio, and the sound now works...
However, this bug is still open because wine should work with alsa without the need of pulseaudio