https://bugs.winehq.org/show_bug.cgi?id=48428
--- Comment #3 from Tomáš Bžatek bugs@bzatek.net --- (In reply to Zhiyi Zhang from comment #2)
Confirmed. Tiled displays are currently unsupported. Wine needs to support RandR 1.5 and TILE property in the outputs.
Thanks for confirming this. Does this qualify as a regression that should be reverted for the stable 5.0 release?
Note that I basically didn't test anything else other than Lightroom, no idea what else is broken.