http://bugs.winehq.org/show_bug.cgi?id=27298
--- Comment #18 from Jonathan Strander mblackwell1024@gmail.com 2012-10-25 23:49:36 CDT --- While the game performance is still very much on the low side depending on the area/scene I have discovered a way to boost overall performance for this game on Wine:
1) Start the game in a new Xserver. This will give a 40-45% (ish) increase in performance (most other games I don't see much noticeable difference).
2) Run the game with (if you have NVIDIA) __GL_THREADED_OPTIMIZATIONS. This gives an additional boost in fps.
The final tally amounted to a 54% gain in a given scene over standard launch. Just running with __GL_THREADED_OPTIMIZATIONS alone is enough to give the game a bit of a performance boost, but surprisingly the new Xserver (not just a non-compositing desktop) does the lion's share by itself.
I'm not sure what it is that causes it to make such a massive difference in this one game.
(tested with NVIDIA Driver v310.14, and Wine 1.5.15)