http://bugs.winehq.org/show_bug.cgi?id=20296
--- Comment #30 from Christoph Hohmann reboot@gmx.ch 2010-08-19 12:41:09 --- It seems the registry keys are not need anymore. Maybe it was just a messed up installation. They were correctly created the last time I tried to install LoL. The launcher crashes when it can not load the COM class, so the missing keys had the same effect as the real problem that Wine does not support loading COM classes in surrogate servers.