http://bugs.winehq.org/show_bug.cgi?id=26924
--- Comment #9 from Joshua wine@placesthroughtime.com 2011-05-19 10:53:27 CDT --- The rads_user_kernel.exe 'attempts' to update itself before it can run LoLLauncher.exe. I'm just taking a shot in the dark here saying that it fails at some point during it's self update process since forcing it to just run seems to work just fine.