http://bugs.winehq.org/show_bug.cgi?id=20609
--- Comment #9 from Kevin Meyer billy65bob@gmail.com 2012-11-03 22:31:58 CDT --- (In reply to comment #8)
still a bug in current wine?
Yes.
NWN2 fails to detect a GPU with at least 128MB of VRAM (warning) and subsequently fails to detect available 3D hardware (error) and exits as a result. Overriding dxdiag to "native" removes the errors and renders the game fully playable.