[Bug 42632] attempt to open Doom wine-2.3 staging fails to open

https://bugs.winehq.org/show_bug.cgi?id=42632

[e-mail] changed:

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--- Comment #3 from [e-mail] ---
(In reply to [e-mail] from comment #0)
> $ /opt/wine-staging/bin/wine64 ./DOOMx64.exe

I may be wrong but it looks like you're trying to run the DOOM executable as if
it were a Linux binary or executable shell script with that

./DOOMx64.exe

You should only need to run

wine DOOMx64.exe

or

wine DOOMx64vk.exe (for the Vulkan version)

Also, do you have the game installed via Steam or what? Because if I am running
the Steam version via the terminal I usually navigate to the following
directory:

/.wine_doom_2016/drive_c/Program Files (x86)/Steam/steamapps/common/DOOM

So you may need to do something similar to my use case....