http://bugs.winehq.org/show_bug.cgi?id=28221
--- Comment #7 from LBM knaprigt@gmail.com 2011-09-09 14:12:49 CDT --- Problem solved, sort of anyway...
By looking at my own logs and your mmdevapi code I noticed that I kept getting Xrun's when the stutter occurred, so I enlarged my Alsa buffer by editing my .asoundrc file and now the stutter is gone.
No idea if you wanna make some kind of adjustment to your code, or if this is even a Wine bug anymore, but at least now we know what caused the problem.