http://bugs.winehq.org/show_bug.cgi?id=28515
--- Comment #5 from Dmitry Timoshkov dmitry@baikal.ru 2011-09-29 06:50:45 CDT --- (In reply to comment #2)
Yes: axel@z60m:~> env WINEPREFIX="/home/axel/.xwine" wine "/home/axel/.wine/drive_c/Programme/GMX/GMX SMS-Manager/SMSMngr.exe"
What's the point to set WINEPREFIX to a different place than the one the program installed into? That setup is invalid and not supported.