https://bugs.winehq.org/show_bug.cgi?id=55927
--- Comment #4 from Fabian Maurer dark.shadow4@web.de --- PlayOnLinux is generally not supported here. You seem to be using a 32bit version of wine which doesn't work with your 64bit WINEPREFIX. Like the error message tells you.
There is no harm downgrading system wine, you can always just update it again later