http://bugs.winehq.org/show_bug.cgi?id=10495
--- Comment #416 from Susan Cragin susancragin@earthlink.net ---
I set pulseaudio autospawn to No, killed pulseaudio, and started Natspeak wine. Natspeak worked great.
Actually, this is wrong. I hadn't uncommented the autospawn setting and pulseaudio was still running. Whoops.