https://bugs.winehq.org/show_bug.cgi?id=44893
--- Comment #20 from winebugs@63bit.net --- No, it still gets locked in loader.c in both new and old versions of SKSE64. OBSE, SKSE, and NVSE work in the same prefix, so it's something specific to 64bit wine or skse64, afaict.
Here's a log with WINEDEBUG=+loaddll https://pastebin.com/65S582ix
Note this particular example involves mono, but not all of them do.