http://bugs.winehq.org/show_bug.cgi?id=34122
--- Comment #7 from Anders Larsson Wicla@thethundertemplars.com 2013-09-01 10:00:30 CDT --- (In reply to comment #6)
This looks like a duplicate of bug 31113, which has a work-around script that seems to be giving mixed results.
Just tried the workaround with a clean Civilization 5 install and it does not fix the bug mentioned in this thread. Elements of the interface is gone in Civilization 5 which makes it impossible to play since you're unable to build buildings/units in cities.