https://bugs.winehq.org/show_bug.cgi?id=46021
--- Comment #1 from roquene@gmail.com --- after further research i found this bug: https://bugs.winehq.org/show_bug.cgi?id=45938 which seemed comparable
and the solution is in fact to compile staging without the patch "server-send_hardware_message"
https://github.com/wine-staging/wine-staging/tree/master/patches/server-send...
fixes the problem in Mass Effect 3