http://bugs.winehq.org/show_bug.cgi?id=30690
--- Comment #1 from Lucas Fialho Zawacki lfzawacki@yahoo.com.br 2012-07-16 22:19:49 CDT --- I tested for this bug with the "Orcs Must Die!" Steam version using Wine 1.5.8 and I can not reproduce. Mouse and keyboard seem to work just fine.
I tried it with a joystick connected to see if it could be a problem, but it works as expected too. The game does hide the mouse pointer when I start pressing the joystick, but it comes back if I touch the mouse again.
OP should retest with newest wine. If the bug is still present post more details. For starters what is the game version, if there's any extra controllers connected and a +dinput log.