https://bugs.winehq.org/show_bug.cgi?id=50449
--- Comment #8 from Rémi Bernon rbernon@codeweavers.com --- I could also see cases where a keyboard key press isn't doing anything if the mouse is moved at the same time. If the key is kept pressed while moving the mouse it's only taking effect after a bit and usually then continues moving even after key is released.
When not using ReShade, all mouse and keyboard movements are very delayed, and wined3d thread are very busy.
ReShade is probably adding more window message processing that is not usually done and from time to time it hands it over to the normal application message processing loop, that suffers from the sluggishness.
Note that I can also reproduce all of this with Wine 5.11, so it may not be the same issue.