http://bugs.winehq.org/show_bug.cgi?id=28898
--- Comment #54 from William Pettersson william.pettersson+wine@gmail.com 2012-03-23 06:36:28 CDT --- Ok, I just realised something really odd (which also explains my slow-downs). Somehow, two copies of Diablo III.exe get launched. As in, two distinct copies of the game. I have to exit one, and then I can play the second one smoothly. If I try to play the first, it's choppy.
I have no idea if this relates to my patch (or even how it could) but if it does get slow, test this for me as well.