http://bugs.winehq.org/show_bug.cgi?id=1158
--- Comment #26 from Paul Vriens Paul.Vriens.Wine@gmail.com 2010-09-25 04:38:48 CDT --- I'd say yes. When you tell Wine to go RTL, menu's are displayed right aligned.
The fact that running notepad (or any Wine app where the translation is done) in a Hebrew environment still has the menu's left-aligned is probably worth another bug.