http://bugs.winehq.org/show_bug.cgi?id=8634
--- Comment #6 from Gareth tgheretford@fast4.net 2008-05-03 15:47:46 --- The Anti-aliasing option seems to be working as of Wine 0.9.61, but I did have to reinstall GTA San Andreas due to a unrelated problem. When I checked the Anti-aliasing option, it worked.
I am guessing that it should work without reinstalling GTA San Andreas.