Waaaay back in 2002, the wine project experimented with writing win32 conformance tests in Perl. Nobody liked it; it was dropped in favor of conformance tests in C, and there was much rejoicing.
Today I noticed http://bugs.winehq.org/show_bug.cgi?id=23940 which has a simple win32 test case written in Python. Surprisingly, with 'winetricks python', the test case ran and demonstrated the problem (though since the python script expected you to start another app first, and edit the python to have the other app's window title, it wasn't an unattended test).
That particular bug isn't anything special, but I was happy to see that a user who preferred Python was able to successfully send a minimal test case for a win32 problem written in his favorite language, and have someone else successfully run it.